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Advancements in Health Research

eISSN 3035-1103

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Editors-in-Chief: Pierangelo Geppetti, Giustino Varrassi, Italy

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  • PAIN IN ANIMALS A.V. Cirillo1, L. Abagnale2, A. Ascione3 | 1Assimefac, National Scientific Society of Family and Community Medicine; 2Former Director of the Prevention Department of the Veterinary Operating Unit, ASL Salerno; 3Anima Iris Integrated Consultation in Clinical Psychology, Pompei

    2025-09-22
    https://doi.org/10.4081/ahr.2025.56
    155
  • DEEP BRAIN STIMULATION FOR REFRACTORY CHRONIC PAIN: CLINICAL TARGETS, INDICATIONS, AND EMERGING STRATEGIES L. Al-Husinat1, S. Azzam1, S. Al Sharie2, A.A. Alomari3, A. Baydoun4, H.B. Yaseen5, G. Varrassi6 | 1Department of General Surgery and Anesthesia, Faculty of Medicine, Yarmouk University, Irbid, Jordan; 2Laboratory of Science and Translation in Critical Illness, Vanderbilt University Medical Center, Nashville, TN, USA; 3Section of Neurosurgery, Department of Special Surgery, Faculty of Medicine, Mutah University, Alkarak, Jordan; 4Unit of Anesthesia, Intensive Care and Pain Therapy, Sant’Andrea University Hospital, Rome, Italy; 5Department of Anesthesia and Intensive care unit, Ministry of Health Educational Hospitals, Amman, Jordan; 6Fondazione Paolo Procacci, Rome, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.147
    106
  • CHRONIC PAIN AND THERAPEUTIC ADHERENCE: PRELIMINARY PHASE OF THE ASST BERGAMO EST PROJECT FOR INTEGRATED TERRITORIAL MANAGEMENT V. Margosio, R. Tortelli, M. Mauri | Local Social and Health Authority (ASST) Bergamo Est, Bergamo

    2025-09-22
    https://doi.org/10.4081/ahr.2025.83
    93
  • RADIOFREQUENCY IN CHRONIC PAIN: EXPERIENCE FROM THE CIRIÈ/LANZO PAIN THERAPY CENTER E. Moriondo, M. Fadde | ASL TO 4 Pain Therapy, Ciriè, Torino

    2025-09-22
    https://doi.org/10.4081/ahr.2025.86
    90
  • MYRELIEF PROJECT: DEVELOPMENT OF AN INTERACTIVE APP FOR INTEGRATED MANAGEMENT OF CHRONIC PAIN C. Bertone, G. Pari, P. Silvegni | Pain Medicine and Therapy Unit, Santa Maria Maddalena Health Clinic, Occhiobello (RO)

    2025-09-22
    https://doi.org/10.4081/ahr.2025.45
    130
  • CHRONIC PAIN PREVALENCE AND ASSESSMENT GAP IN ITALIAN PUA/UVM PATIENTS: A CROSS-SECTIONAL STUDY G. Fedelfranco | Social Health Local District of Bari, Unified Access Point / Multidimensional Assessment Unit, Bari; University of Bari "Aldo Moro", Bari, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.160
    68
  • SOCIO-PSYCHOLOGICAL FACTORS AS PREDICTORS OF PAIN CHRONICITY: A CASE SERIES OF THREE PATIENTS WITH MULTILEVEL SPINAL DISORDERS A. Telesca, G. Mazzaglia, M. Consonni, M. Gemma | Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano

    2025-09-22
    https://doi.org/10.4081/ahr.2025.112
    85
  • INTESTINAL FUNGAL DYSBIOSIS AS A POTENTIAL CONTRIBUTOR TO CHRONIC LOW BACK PAIN: A CASE SERIES J. Mendoza | Antioquia Society of Anesthesiology and Resuscitation (SADEA), Medellin, Colombia

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.174
    91
  • Exercise pain and alexithymia: exploring the relationship

    Maria Matsangidou, Jakob W.C. Yianni, Alexis R. Mauger
    2026-02-19
    https://doi.org/10.4081/ahr.2026.128
    180
    PDF: 540
  • SPECIFICITY OF PAIN PERCEPTION AND REPORTING IN OLDER ADULTS: A RETROSPECTIVE STUDY U. Michalik-Marcinkowska1, D. Myrcik2, G. Varrassi3 | 1Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Poland; 2Department of Propaedeutics of Internal Diseases and Emergency Medicine, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Poland; 3Fondazione Paolo Procacci, Rome, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.175
    48
  • CHRONIC PAIN TREATMENT DURING PREGNANCY: NAVIGATING THE EVIDENCE GREY ZONE G. Di Giuseppe, I. Olivieri, C. Angeletti | Department of Anaesthesia, Intensive Care and Pain Medicine, Mazzini Hospital, Teramo, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.157
    81
  • CLINICAL PROFILE, TREATMENT PATTERNS, AND EXPECTATIONS OF PATIENTS REFERRED TO A CHRONIC PAIN CENTER: A RETROSPECTIVE CROSS-SECTIONAL STUDY J. Nicolas, M. D'Ussel | Chronic Pain Center, Paris Saint-Joseph Hospital, Paris, France

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.179
    56
  • Reframing chronic pain through the microbiota-gut-brain axis: from mechanisms to clinical meaning

    Kakhaber Chelidze, Matteo Luigi Giuseppe Leoni, Dariusz Myrcik, Y Van Tran, Phong Van Pham, Giustino Varrassi
    2026-06-04
    https://doi.org/10.4081/ahr.2026.139
    201
    PDF: 148
    Supplementary: 18
  • CHRONIC VISCERAL PAIN TREATED WITH 10 khz SPINAL CORD STIMULATION: A CASE REPORT L. Sandroni, M. Parolini | Pain Therapy Center, Complex Operating Unit (UOC), AUSL Toscana South East, Arezzo

    2025-09-22
    https://doi.org/10.4081/ahr.2025.100
    145
  • ERECTOR SPINAE PLANE BLOCK AND OZONE THERAPY: THE INNOVATIVE ALLIANCE AGAINST CHRONIC DISCOGENIC BACK PAIN S. Sorrenti1, M. Ciuffreda1, E. Pisello1, L. Brugiaferri2, A. Federici2, C. Piangatelli3, D. Galante4 | 1U.O.C. Anesthesia Resuscitation Pain Therapy, AST Ancona, Fabriano (AN); 2Residency School. Anesthesia, Resuscitation, Intensive and Pain Therapy, Università Politecnica delle Marche, Ancona; 3U.O.C. Anesthesia, Resuscitation Pain Therapy, Director, AST Ancona, Fabriano (AN); 4U.O.C. Anesthesia and Resuscitation, Director, Cerignola (FG)

    2025-09-22
    https://doi.org/10.4081/ahr.2025.106
    185
  • WOUND PAIN ASSESSMENT IN ITALIAN DOMICILIARY PALLIATIVE CARE: AN AUDIT OF LAW 38/2010 COMPLIANCE IN HOMENURSING G. Fedelfranco | Social Health Local District of Bari, Unified Access Point (PUA) / Multidimensional Assessment Unit (UVM), Bari; University of Bari "Aldo Moro", Bari, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.163
    51
  • NURSE BURNOUT AND THE BIOPSYCHOSOCIAL PAIN ASSESSMENT GAP: A CROSS-SECTIONAL STUDY IN ITALIAN COMMUNITY NURSING G. Fedelfranco | Social Health Local District of Bari, Unified Access Point  / Multidimensional Assessment Unit, Bari; University of Bari "Aldo Moro", Bari, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.164
    55
  • PAIN AS A NEUROCARDIAC STRESSOR: REFRAMING PAIN BEYOND NOCICEPTION C. Angeletti1, G. Di Giuseppe1, I. Olivieri1, G. Varrassi2 | 1Department of Anaesthesia, Intensive Care and Pain Medicine, Mazzini Hospital, Teramo, Italy; 2Fondazione Paolo Procacci, Rome, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.150
    109
  • ULTRASOUND-GUIDED CRYONEUROLYSIS: A NOVEL APPROACH TO PAIN MANAGEMENT IN RHEUMATOID ANKLE AND FOOT ARTHRITIS A. Allam1, M. Hassanien2, A.O.M. Abdallah3, K.H.S. Lam4|5|6, T.K. Ng7|8|9|10, T. Ergönenç11, F. Occhigrossi12 | 1Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assuit University, Assuit, Egypt; 3Department of Anesthesia and Intensive Care, Faculty of Medicine, New Valley University, New Valley, Egypt; 4Department of Family Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong; 5Department of Family Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; 6Department of Clinical Research, The International Association of Musculoskeletal Medicine, Kowloon Bay, Kowloon, Hong Kong, China; 7Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China; 8Department of Anaesthesia, Boxhill Hospital, Melbourne, Australia; 9Frankston Pain Management, Melbourne, Australia; 10Department of Anaesthesia and Operating Theatre Services, Tuen Mun Hospital, Tuen Mun, Hong Kong, China; 11Anesthesia and Reanimation, Pain and Palliative Care, Akayazi Hospital, Sakarya, Turkey; 12Pain Therapy Unit, San Giovanni-Addolorata Hospital, Rome, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.148
    123
  • FROM PHENOTYPE TO GENOTYPE: DO COMT, MTHFR, BDNF, OPRM1, AND HTR2A POLYMORPHISMS CONTRIBUTE TO CHRONIC MUSCULOSKELETAL PAIN? H. Demir Usan | Faculty of Medicine, Yuksek Ihtisas University, Ankara, Turkey

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.156
    78
  • Predictive factors for the efficacy of myofascial infiltration in chronic cervicalgia: implications for technique indication criteria

    María José Groizard Botella, Adriana M. Buriticá Aguirre, Marco Palumbo, Mercè Matute Crespo, F. Javier Vilà Justribó, Antonio Montero Matamala
    2025-02-19
    https://doi.org/10.4081/ahr.2025.32
    901
    PDF: 336
  • OVERLAPPING CHRONIC PAIN S. Agachi1, L. Groppa1, O. Bujor2, R. Usatîi2, L. Taran2, A. Lesnic2 | 1Department of Rheumatology and Nephrology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova; 2Clinical Republican Hospital Timofei Mosneaga, Chisinau, Republic of Moldova

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.146
    77
  • QUALITY OF LIFE AND PAIN PERCEPTION IN PATIENTS WITH PRIMARY CHRONIC MUSCULOSKELETAL PAIN FOLLOWING SELF-MANAGEMENT INTERVENTIONS M. Sangheli1, S. Pleșca2, M. Bulai2 | 1Department of Neurology no.1, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova; 2Department of Medical Rehabilitation, Physical Medicine and Manual Therapy, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.191
    62
  • INTRATHECAL MORPHINE THERAPY FOR CHRONIC BENIGN NEUROPATHIC PAIN: A CASE REPORT V. Donatiello1, M. Alfieri2, A. Scalvenzi1, F. Mattozzi2, A. Cangiano2, A.R. Tonci2, P. Buonavolontà2 | 1Dept. of Elective Anesthesiological Activities ", "AORN A. Cardarelli" Hospital Napoli; 2Pain Unit "AORN A. Cardarelli" Hospital, Napoli

    2025-09-22
    https://doi.org/10.4081/ahr.2025.62
    125
  • PAIN IN CHILDREN: A SYSTEMATIC REVIEW OF PRIMARY SOURCES G. Fedelfranco1, F. Caramia2 | 1Social Health District ASL Bari, U.O. PUA/UVM (Single Access Door Operating Unit/Multidimensional Evaluation Unit), Bari; 2ASL Local Health Authority, Brindisi

    2025-09-22
    https://doi.org/10.4081/ahr.2025.69
    119
  • MESOTHERAPY COMBINED WITH REGENERATIVE MEDICINE. A NEW APPROACH FOR NOCICEPTIVE PAIN TREATMENT IN PATIENTS WITH OSTEOARTHROSIS A. Bertolino1, A. Maxia2, B. Pani2, M. Ollosu2, S. Sardo2 | 1Anesthesia, Intensive Care and Pain Therapy Unit, AOU Cagliari; 2Department of Medical Sciences and Public Health, University of Cagliari

    2025-09-22
    https://doi.org/10.4081/ahr.2025.44
    158
  • NOTALGIA PARESTHETICA: CASE REPORT ON THERAPEUTIC MANAGEMENT WITH ULTRASOUND-GUIDED OZONE MESOTHERAPY S. Sorrenti1, M. Ciuffreda1, E. Pisello1, C. Pellegrino2, A. Monacelli2, G. Cucè4, C. Piangatelli1, D. Galante4 | 1Department of Anesthesiology, Intensive Care and Pain Management, AST Ancona, Fabriano (AN), Italy; 2Department of Anesthesiology, Intensive Care and Pain Management, Marche Polytechnic University, Ancona, Italy; 3Department of Public Health, University of Messina, Italy; 4Department of Anesthesiology, Intensive Care and Pain Management, ASL Foggia, Cerignola (FG), Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.198
    58
  • Emerging potential therapies for chronic abdominal visceral pain: an overview

    Martina Rekatsina, Giustino Varrassi
    2024-03-18
    https://doi.org/10.4081/ahr.2024.2
    3916
    PDF: 584
  • Effectiveness of the erector spinae plane block for the management of persistent pain after lumbar surgery: a prospective study

    Luis Carvalheiro Fagulha, Antonio Montero
    2025-01-22
    https://doi.org/10.4081/ahr.2025.21
    1064
    PDF: 383
  • LONG-TERM MULTIMODAL CONTROL OF SPINAL PAIN AND EARLY SIGNS OF SENILE DEMENTIA WITH MICRO-PEA, LOW-DOSE GABAPENTIN AND PHYSIOTHERAPY. A CASE REPORT IN A GERIATRIC DOG M. Speciani1, G. Morelli2 | 1Veterinary Doctor, Mantova; 2Innovet Italia srl, Padova

    2025-09-22
    https://doi.org/10.4081/ahr.2025.109
    151
  • CLINICAL USE OF MEDICAL CANNABIS IN A COHORT OF PATIENTS WITH CHRONIC PAIN AND COGNITIVE DECLINE: FOCUS ON NEUROPSYCHIATRIC SYMPTOM RELIEF P. Krasniqi1, G. Guerrieri2 | 1Emergency Department - Usl Umbria2, Anaesthesia, Resuscitation and Pain Therapy Department of Narni and Amelia, Narni (Terni); 2Anaesthesia, Resuscitation Department, Narni

    2025-09-22
    https://doi.org/10.4081/ahr.2025.78
    99
  • EVALUATION OF PAIN IN FIBROMYALGIA PATIENTS TREATED WITH CANNABIS OIL G. Sola1, S. Penpa2, G. Piceni2, G. Bo3, L. Ventura1, F. Cassini1, L. Savi3, G. Cammarota4, R. Cutaia3, A. Maconi2 | 1SSD Pain Unit, "SS Antonio e Biagio e Cesare Arrigo" Hospital, Alessandria; 2Research Training Innovation Infrastructure, Reseaerch and innovation, Department, "SS Antonio e Biagio e Cesare Arrigo" Hospital, Alessandria; 3SC Hospital pharmacy and management of devices and drugs, "SS Antonio e Biagio e Cesare Arrigo" Hospital, Alessandria; 4Anesthesia and resuscitation, "SS Antonio e Biagio e Cesare Arrigo" Hospital, Alessandria

    2025-09-22
    https://doi.org/10.4081/ahr.2025.105
    162
  • MULTIDISCIPLINARY MANAGEMENT OF REFRACTORY FAILED BACK SURGERY SYNDROME: A COMPLEX CASE REPORT WITH MULTIMODAL INTERVENTIONS AND LITERATURE REVIEW D. Gemma1, G. Pulito2 | 1"Cardinale G. Panico" Hospital, Tricase (Lecce); 2"V. Fazzi" Hospital, Lecce

    2025-09-22
    https://doi.org/10.4081/ahr.2025.75
    84
  • GENDER DIFFERENCES IN THE PRESENTATION AND MANAGEMENT OF CHRONIC PAIN: EVIDENCE FROM AN OBSERVATIONAL STUDY L. Farina1, A.A. Carrideo1, N. Di Francesco1, T. Di Foggia1, C. Gallo2, G. Cinnella1 | 1Pain Therapy Clinic Ambulatory, Foggia University Hospital, Foggia, Italy; 2Department of Clinical and Experimental Medicine, University of Foggia, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.159
    84
  • OPIOID-SPARING EFFECT OF LIDOCAINE, KETAMINE AND MAGNESIUM IN THORACOTOMY J. Herrera Silva1, S.T. Bahí2, M. Díaz2, I. Gascó2, C. Rodriguez3, X. Baldó3, M. Vives4 | 1Department of Anesthesia, Reanimation and Pain Unit, Dr. Bofill Clinic - University Hospital Dr. J. Trueta, Girona, Spain; 2Department of Anesthesia & Reanimation, Hospital Universitari Dr. J. Trueta, Girona, Spain; 3Department of Anesthesia & Thoracic Surgery, University Hospital Dr. J. Trueta, Girona, Spain; 4Department of Anesthesia & Critical Care Medicine, Clinica Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Spain

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.166
    69
  • SYSTEMIC OZONE THERAPY FOR CHRONIC MIGRAINE: IMPACT ON DISABILITY, MEDICATION USE, AND SLEEP QUALITY IN A FEMALE PATIENT GROUP S. Sorrenti1, M. Ciuffreda1, E. Pisello1, L. Brugiaferri2, A. Federici2, C. Piangatelli3, D. Galante4 | 1U.O.C. Anesthesia Resuscitation Pain Therapy, AST Ancona, Fabriano (AN); 2Residency School. Anesthesia, Resuscitation, Intensive and Pain Therapy, Università Politecnica delle Marche, Ancona; 3U.O.C. Anesthesia, Resuscitation, Pain Therapy, Director, AST Ancona, Fabriano (AN); 4U.O.C. Anesthesia and Resuscitation, Director, Cerignola (FG)

    2025-09-22
    https://doi.org/10.4081/ahr.2025.107
    178
  • REGENERATIVE ULTRASOUND-GUIDED PRP PLUS HYALURONIC ACID PROVIDES DURABLE PAIN CONTROL IN KNEE OSTEOARTHRITIS V. Caminiti | Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli" of Reggio Calabria, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.153
    243
  • COMBINED USE OF PALMITOYLETHANOLAMIDE + EQUISETUM AND ACETYL L-CARNITINE BEFORE AND AFTER RACZ PERIDURAL ADHESIOLYSIS AND LUMBAR GANGLION NEUROMODULATION C. Paoletti, L.F. Nardi, F. Del Sordo | Pain Relief Surgery Unit, Casa di Cura Villa Igea, Ancona

    2025-09-22
    https://doi.org/10.4081/ahr.2025.89
    204
  • RADIOFREQUENCY DENERVATION IN THE MANAGEMENT OF SACROILIAC JOINT PAIN: A COMPARATIVE STUDY OF TWO TECHNIQUES E. Antognozzi1, G. Biondi2, A. Gioia2, E. Piraccini2, P. Pogliaghi3, M.C. Tonnarelli3 | 1Department of Anaesthesia and Intensive Care, Hospital of San Benedetto del Tronto (AP), Italy; 2Pain Therapy Center, Bellaria Hospital, Bologna, Italy; 3Department of Anaesthesia and Intensive Care, Hospital of Bentivoglio (BO), Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.151
    72
  • EMOTIONAL PAIN IN OLDER ADULTS: DETERMINANTS AND CLINICAL CORRELATES U. Michalik-Marcinkowska1, D. Myrcik2, G. Varrassi3 | 1Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Poland; 2Department of Propaedeutics of Internal Diseases and Emergency Medicine, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Poland; 3Fondazione Paolo Procacci, Rome, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.176
    49
  • REAL-WORLD TITRATION PATHWAYS AND THERAPEUTIC INTEGRATION OF MEDICAL CANNABIS IN FIBROMYALGIA: INTERIM ANALYSIS OF A REFRACTORY CLINICAL COHORT I. Olivieri, G. Di Giuseppe, R. Berrettoni, C. Angeletti | Department of Anaesthesia, Intensive Care and Pain Medicine, Mazzini Hospital, Teramo, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.181
    64
  • The drug called food and its role as a therapy for chronic patients: a comprehensive narrative review

    Giustino Varrassi, Emanuele Cereda, Giovanni A. Ruoppolo, Marco Mercieri, Maurizio Muscaritoli
    2024-05-07
    https://doi.org/10.4081/ahr.2024.6
    3248
    PDF: 574
  • TOWARDS EARLY PERSONALIZED TREATMENT OF LUMBAR DISC HERNIATION: DEVELOPMENT OF A SUPERVISED DEEP LEARNING PREDICTIVE MODEL I. Curto1, G. Vasarri2 | 1Neurosurgical Intensive Care, "Santa Chiara" Hospital, Trento; 2Dept. of Anesthesiology and Resuscitation, Ospedale" San Jacopo", Pistoia

    2025-09-22
    https://doi.org/10.4081/ahr.2025.58
    198
  • Image from Pixabay

    Harnessing the healing power of creativity: exploring the role of art in healthcare through art, dance, and music therapy

    Alberto Corriero, Mariateresa Giglio, Rossana Soloperto, Giustino Varrassi, Filomena Puntillo
    2024-07-11
    https://doi.org/10.4081/ahr.2024.17
    2722
    PDF: 1221
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