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Advancements in Health Research

eISSN 3035-1103

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Editors-in-Chief: Pierangelo Geppetti, Giustino Varrassi, Italy

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  • Opioids as part of responsible pain management: a global crisis of extremes

    Frank J. Breve, Giustino Varrassi, Joseph V. Pergolizzi, Jr., Robert B. Raffa
    2026-10-01
    https://doi.org/10.4081/ahr.2026.210
    0
    Downloads: 0
  • Advancements in the treatment of pain: not all opioids are the same

    Robert B. Raffa
    2024-05-20
    https://doi.org/10.4081/ahr.2024.3
    1715
    Downloads: 474
  • NEUROAURICOLOTHERAPY FOR OPIOID ABUSE IN CHRONIC BENIGN PAIN E. Fanzago | Anesthesiologist and Pain Therapist, Torino

    2025-09-22
    https://doi.org/10.4081/ahr.2025.66
    113
  • METHADONE CONVERSING USING IN THREE PATIENTS WITH CANCER ON HIGH-DOSE OPIOIDS: TWO MODELS SWITCH STRATEGY “3-DAY” OR “STOP AND GO”: PAIN-RELIEF, MISTRUST, ENVIRONMENTAL DIFFICULTIES M. Forte1, M. Cascella2, I. Iannone1, C. Abagnale1, N. Gallo1, A. Alfano1, F. Monaco3, C. Della Corte1, F. Morgillo1, T. Troiani1, M. .C. Pace1, P. Sansone1, M.B. Passavanti1 | 1Università degli Studi della Campania AOU “L. Vanvitelli”, Napoli, Italy; 2Università degli Studi di Salerno, Fisciano (SA), Italy; 3Ospedale San Paolo, Napoli, Italy

    2026-09-21
    https://doi.org/10.4081/ahr.2026.253
    4
  • UNDERUSE OF NALDEMEDINE IN OPIOID-TREATED PATIENTS: ITALIAN REAL-WORLD EVIDENCE A. Ungar1, A. Cuomo2, F. Radaelli3, S. Calabria4, M. Leogrande4, M. Capacci5, M. Torrini6, L. Degli Esposti4 | 1Head division of Geriatrics and Intensive Care Unit, Università di Firenze, Italy; 2IRCCS Istituto Nazionale Tumori Fondazione, Napoli, Italy; 3UOC di Gastroenterologia, Ospedale Valduce, Como, Italy; 4CliCon S.r.l. Società Benefit, Bologna, Italy; 5SOD Geriatria per l'Alta Intensità e Cardiologia Geriatrica, AOU Careggi e Università degli Studi di Firenze, Italy; 6Geriatrics Unit for High Care Complexity, Università di Firenze, Italy

    2026-09-21
    https://doi.org/10.4081/ahr.2026.292
    1
  • PALMITOYLETHANOAMIDE ULTRAMICRONIZED IN PEDIATRIC PATIENTS AFTHER LIMB ELONGATION SURGERY S. Kotzeva1, A. Wolfler1, L. Palomba2, D. Innocenti2 | 1IRCCS Giannina Gaslini UOC Anesthesiology and acute and procedural pain therapy, Genoa; 2IRCCS Giannina Gaslini, Genoa

    2025-09-22
    https://doi.org/10.4081/ahr.2025.77
    152
  • EMERGING DRUGS OF ABUSE IN THE CHRONIC PAIN POPULATION: A CLINICAL PHARMACOLOGY PERSPECTIVE ON KRATOM, NOVEL SYNTHETIC OPIOIDS, DESIGNER BENZODIAZEPINES, GABAPENTINOIDS, XYLAZINE, AND KETAMINE F. Breve1, G. Varrassi2, J. Pergolizzi3, R. Raffa4 | 1Mid Atlantic PharmaTech Consultants LLC, Ventnor City, NJ, USA; Temple University School of Pharmacy, Philadelphia, PA, USA; 2Fondazione Paolo Procacci, Rome, Italy; 3NEMA Research Inc., Naples, FL, USA; 4Temple University School of Pharmacy, Philadelphia, PA, USA; University of Arizona College of Pharmacy, Tucson, AZ, USA

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.152
    171
  • IMPACT OF A HOSPITAL PAIN THERAPY UNIT ON OPIOID PRESCRIPTION APPROPRIATENESS AND CONSUMPTION REDUCTION: A RETROSPECTIVE ANALYSIS P. Buonavolontà1, V. Donatiello2, M. Alfieri1, A. Scalvenzi2, A. Frangiosa2, G.M. Casillo3, A. Altiero3, R. Mercogliano3, G. Guglielmi3 | 1Pain Therapy Center, "A. Cardarelli" Hospital, Napoli; 2Dept. of Elective Anesthesiological Activities, "A. Cardarelli" Hospital, Napoli; 3Dept. of Pharmacology, "A. Cardarelli" Hospital, Napoli

    2025-09-22
    https://doi.org/10.4081/ahr.2025.51
    155
  • EFFICACY AND SAFETY OF THE FIXED DOSE COMBINATION OF ACETAMINOPHEN AND TRAMADOL IN THE MANAGEMENT AND TREATMENT OF PAIN: A SYSTEMATIC REVIEW AND META-ANALYSIS D. Scaturro1, S. Tomasello2, M. Mangrelli3, D. Trastulli3, R. Piazza3, G. Letizia Mauro1 | 1Department of Precision Medicine in the Medical, Surgical and Critical Care Area, University of Palermo, Italy; 2Palermo Provincial Health Authority, Palermo, Italy; 3Italfarmaco SpA, Medical Affairs Department, Milan, Italy

    2026-09-21
    https://doi.org/10.4081/ahr.2026.279
    1
  • PERSISTENT OPIOID USE AFTER INTENSIVE CARE ADMISSION: A 10-YEAR OBSERVATIONAL POPULATION-BASED COHORT STUDY IN A NORTHERN ITALIAN HOSPITAL V. Damico | PhD, University of Milano-Bicocca, School of Nursing, ASST Lecco

    2025-09-22
    https://doi.org/10.4081/ahr.2025.59
    176
  • RESULTS OF TRANSVERSUS ABDOMINIS PLANE BLOCK AS A COMPONENT OF MULTIMODAL ANALGESIA IN LIVING LIVER DONORS R. Ibadov1, S. Ibragimov2, S. Ergashev2 | 1Intensive Care Unit, Republican Specialized Scientific and Practical Medical Center of Surgery named after academician V.Vakhidov, Tashkent, Uzbekistan; 2Republican Specialized Scientific and Practical Medical Center of Surgery named after academician V.Vakhidov, Tashkent, Uzbekistan

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.167
    69
  • Drug-associated delirium: basic pharmacologic principles and clinical considerations. A narrative review

    Phat H. Le, William C. Upshaw, Tyler A. Le, Horace Townsend, Thanh P.D. Vu, Jill M. Salonga, Taylor Moss, Sridhar Tirumala, Sahar Shekoohi, Adam M. Kaye, Alan D. Kaye
    2025-02-25
    https://doi.org/10.4081/ahr.2025.28
    4014
    Downloads: 4025
  • MULTIDISCIPLINARY MANAGEMENT OF REFRACTORY FAILED BACK SURGERY SYNDROME: A COMPLEX CASE REPORT WITH MULTIMODAL INTERVENTIONS AND LITERATURE REVIEW D. Gemma1, G. Pulito2 | 1"Cardinale G. Panico" Hospital, Tricase (Lecce); 2"V. Fazzi" Hospital, Lecce

    2025-09-22
    https://doi.org/10.4081/ahr.2025.75
    138
  • ADVANCES IN THE PATHOPHYSIOLOGY AND MANAGEMENT OF CANCER PAIN: A SCOPING REVIEW Y. Tran Van1, A. Paladini2, V.P. Pham1, A.A. Al Alwany3, G. Farì4, A. Caruso5, M. Mercieri6, M.L.G. Leoni7, J.V. Pergolizzi8, A.D. Kaye9, F. Breve10, A. Corriero11, C. Gharibo12, G. Varrassi13 | 1Department of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City, Vietnam; 2Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; 3College of Medicine, University of Baghdad, Iraq; 4Department of Experimental Medicine (Di.Me.S.), University of Salento, Lecce, Italy; 6Department of Surgery, ASST Lodi, Lodi, Italy; 7Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Italy; 8NEMA Research Inc., Naples, FL, USA; 9Department of Anesthesiology, LSU Health, Shreveport, LA, USA; 10School of Pharmacy, Temple University, Philadelphia, PA, USA; 11Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy; 12Department of Anesthesiology, NYU Grossman School of Medicine, New York, NY, USA; 13Fondazione Paolo Procacci, Rome, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.202
    99
  • LUMBAR ERECTOR SPINAE PLANE BLOCK AS AN ALTERNATIVE POSTOPERATIVE ANALGESIA METHOD AFTER ACETABULAR SURGERY V. Sharipova1, I. Fokin2, S. Yuldosheva3 | 1Anesthesiology and Critical Care Unit, Republican Scientific Emergency Medical Centre, Tashkent, Uzbekistan; 2Head of Department of Anesthesiology, Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan; 3Department of Anesthesiology, Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.195
    80
  • AN ENGAGING EXPLORATION IN THE A.O. “S. CROCE E CARLE” CUNEO EMERGENCY DEPARTMENT S. Pletto1, G. Martini2, J. Giamello2, M. Giraudo2, M. Garnero2, G. Lauria2 | 1University of Turin, Department of Clinical and Biological Sciences, Turin; 2Emergency Department, ASO Santa Croce e Carle, Cuneo

    2025-09-22
    https://doi.org/10.4081/ahr.2025.98
    172
  • INTRATHECAL MORPHINE THERAPY FOR CHRONIC BENIGN NEUROPATHIC PAIN: A CASE REPORT V. Donatiello1, M. Alfieri2, A. Scalvenzi1, F. Mattozzi2, A. Cangiano2, A.R. Tonci2, P. Buonavolontà2 | 1Dept. of Elective Anesthesiological Activities ", "AORN A. Cardarelli" Hospital Napoli; 2Pain Unit "AORN A. Cardarelli" Hospital, Napoli

    2025-09-22
    https://doi.org/10.4081/ahr.2025.62
    162
  • EFFICACY OF LUMBAR ERECTOR SPINAE PLANE BLOCK FOR POSTOPERATIVE ANALGESIA AFTER ACETABULAR FRACTURE SURGERY: A RANDOMIZED CONTROLLED TRIAL V. Sharipova1, I. Fokin2, S. Yuldosheva3 | 1Anesthesiology and Critical Care Unit, Republican Scientific Emergency Medical Centre, Tashkent, Uzbekistan; 2Head of Department of Anesthesiology, Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan; 3Department of Anesthesiology, Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.194
    93
  • VAGAL NEUROMODULATION FOR DRUG-RESISTANT TRIGEMINAL NEURALGIA: A CASE SERIES C. Tuccillo1, A.M. Salzano2, M.T. Di Dato2, A. Diana1, C. Morrone1, M.B. Passavanti3, C. Pace3, E. Saracco2, M.V. Adriani2, P. Mango2, D. Tammaro2, A. Papa2 | 1Residency Program in Anesthesiology, Resuscitation, Intensive and Pain Therapy University of Campania "Luigi Vanvitelli", Napoli, Italy; 2Pain Department, A.O. Dei Colli - V. Monaldi Hospital, Napoli, Italy; 3Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Napoli, Italy

    2026-09-21
    https://doi.org/10.4081/ahr.2026.291
    1
  • SOCIO-PSYCHOLOGICAL FACTORS AS PREDICTORS OF PAIN CHRONICITY: A CASE SERIES OF THREE PATIENTS WITH MULTILEVEL SPINAL DISORDERS A. Telesca, G. Mazzaglia, M. Consonni, M. Gemma | Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano

    2025-09-22
    https://doi.org/10.4081/ahr.2025.112
    113
  • BREAKTHROUGH CANCER PAIN, NEUROPATHIC PAIN FEATURES, AND OLDER AGE GREATLY INFLUENCE TELEMEDICINE-BASED FOLLOW-UP INTENSITY FOR CANCER PAIN MANAGEMENT D. Esposito1, S. Romano1, M. Montedoro1, S. De Angelis1, G. Izzo1, V. Cerrone1, M.P. Bruno1, F. Monaco2, M. Cascella1 | 1Oncology, Ruggi Hospital, Salerno; 2ASL Napoli 1, Napoli

    2025-09-22
    https://doi.org/10.4081/ahr.2025.63
    194
  • THERAPEUTIC CANNABIS AND OPIOID REDUCTION IN CHRONIC PAIN: CURRENT EVIDENCE AND CLINICAL PERSPECTIVES I. Olivieri, G. Di Giuseppe, C. Angeletti | Anestesia, Rianimazione, Terapia del dolore, Ospedale G. Mazzini, Teramo, Italy

    2026-09-21
    https://doi.org/10.4081/ahr.2026.271
    2
  • POST-ACTINIC PLEXUS NEUROPATHY TREATED WITH SPINAL CORD STIMULATION IMPLANT M. Toma, D. Alicino, L. Fiore, G. Pulito | Dept. of Anesthesia and Resuscitation, "Vito Fazzi" Hospital, Lecce

    2025-09-22
    https://doi.org/10.4081/ahr.2025.113
    90
  • LOCOREGIONAL ANESTHESIA FOR POSTOPERATIVE PAIN MANAGEMENT IN BURN PATIENTS UNDERGOING ESCHARECTOMY AND AUTOLOGOUS SKIN GRAFT SURGERY V. Fabbricatore1, V. Pota2, F. Coppolino2, F. Coletta3, A. Tomasello3, P. Sansone2, M. Fiore2, M.B. Passavanti2, R. Villani3, M.C. Pace2 | 1Residency Program in Anesthesiology, Resuscitation, Intensive and Pain Therapy University of Campania "Luigi Vanvitelli", Napoli; 2Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Napoli; 3Emergency Anesthesia, Burn Intensive Care Unit and Poison Control, AORN Antonio Cardarelli Hospital, Naples, Italy

    2025-09-22
    https://doi.org/10.4081/ahr.2025.64
    209
  • REAL-WORLD TITRATION PATHWAYS AND THERAPEUTIC INTEGRATION OF MEDICAL CANNABIS IN FIBROMYALGIA: INTERIM ANALYSIS OF A REFRACTORY CLINICAL COHORT I. Olivieri, G. Di Giuseppe, R. Berrettoni, C. Angeletti | Department of Anaesthesia, Intensive Care and Pain Medicine, Mazzini Hospital, Teramo, Italy

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.181
    99
  • AGE- AND SEX-RELATED DIFFERENCES IN RESPONSE TO ANALGESIC TREATMENTS IN CHRONIC PAIN PATIENTS: A REAL-WORLD OBSERVATIONAL STUDY S. Stimolo1, S. Zappalà1, M. Maria2, S. Brundo2, R. Chiaramonte2, E. Buccheri2, S. Caramma2 | 1Università di Padova, Italy; 2Policlinico di Catania, Italy

    2026-09-21
    https://doi.org/10.4081/ahr.2026.288
    3
  • CLINICAL PROFILE, TREATMENT PATTERNS, AND EXPECTATIONS OF PATIENTS REFERRED TO A CHRONIC PAIN CENTER: A RETROSPECTIVE CROSS-SECTIONAL STUDY J. Nicolas, M. D'Ussel | Chronic Pain Center, Paris Saint-Joseph Hospital, Paris, France

    Fondazione Paolo Procacci
    2026-05-06
    https://doi.org/10.4081/ahr.2026.179
    86
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Advancements in Health Research

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eISSN: 3035-1103

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